Coronavirus membrane fusion mechanism offers a potential target for antiviral development
Abstract The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …
[HTML][HTML] Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells
During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane
The entry of SARS-CoV-2 into host cells depends on the refolding of the virus-encoded
spike protein from a prefusion conformation, which is metastable after cleavage, to a lower …
spike protein from a prefusion conformation, which is metastable after cleavage, to a lower …
[HTML][HTML] Mechanisms of coronavirus cell entry mediated by the viral spike protein
Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm.
To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with …
To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with …
The molecular biology of coronaviruses
PS Masters - Advances in virus research, 2006 - Elsevier
Coronaviruses are large, enveloped RNA viruses of both medical and veterinary
importance. Interest in this viral family has intensified in the past few years as a result of the …
importance. Interest in this viral family has intensified in the past few years as a result of the …
The SARS-CoV fusion peptide forms an extended bipartite fusion platform that perturbs membrane order in a calcium-dependent manner
Coronaviruses (CoVs) are a major infectious disease threat and include the pathogenic
human pathogens of zoonotic origin: severe acute respiratory syndrome CoV (SARS-CoV) …
human pathogens of zoonotic origin: severe acute respiratory syndrome CoV (SARS-CoV) …
Architecture of the SARS coronavirus prefusion spike
DR Beniac, A Andonov, E Grudeski… - Nature structural & …, 2006 - nature.com
The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia
termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto …
termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto …
Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge
C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
The global coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …
Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion …
Many viral fusion proteins are primed by proteolytic cleavage near their fusion peptides.
While the coronavirus (CoV) spike (S) protein is known to be cleaved at the S1/S2 boundary …
While the coronavirus (CoV) spike (S) protein is known to be cleaved at the S1/S2 boundary …
A review of vaccine research and development: human acute respiratory infections
MP Girard, T Cherian, Y Pervikov, MP Kieny - Vaccine, 2005 - Elsevier
Worldwide, acute respiratory infections (ARIs) constitute the leading cause of acute
illnesses, being responsible for nearly 4million deaths every year, mostly in young children …
illnesses, being responsible for nearly 4million deaths every year, mostly in young children …