The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …

Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to
a living environment of various stresses and pathological stimuli, podocytes are prone to …

T cells play an important role in the development of focal segmental glomerulosclerosis
(FSGS). The mechanism underlying such T cell‐based kidney disease, however, remains …

Podocytes are essential to the structure and function of the glomerular filtration barrier;
however, they also exhibit increased expression of MHC class II molecules under …

Focal segmental glomerular sclerosis (FSGS) is a devastating disease with limited treatment
options and poor prognosis. Activated JAK-STAT signaling has been implicated in other …

Complement factor H (CfH) is a key regulator of the alternative pathway, and its presence on
mouse platelets and podocytes allows the processing of immune complexes. Because of the …

Complement constitutes a major part of the innate immune system. The study of complement
in human health has historically focused on infection risks associated with complement …

Kidney glomerulosclerosis commonly progresses to end-stage kidney failure, but
pathogenic mechanisms are still poorly understood. Here, we show that podocyte …

Our understanding of the complement system has markedly evolved from its early
beginnings as a protein system merely detecting and tagging a pathogen for further …