Plant natural products targeting bacterial virulence factors

LN Silva, KR Zimmer, AJ Macedo, DS Trentin - Chemical reviews, 2016 - ACS Publications
Decreased antimicrobial efficiency has become a global public health issue. The paucity of
new antibacterial drugs is evident, and the arsenal against infectious diseases needs to be …

Microbial biosurfactant research: time to improve the rigour in the reporting of synthesis, functional characterization and process development

MS Twigg, N Baccile, IM Banat, E Déziel… - Microbial …, 2021 - Wiley Online Library
The demand for microbially produced surface‐active compounds for use in industrial
processes and products is increasing. As such, there has been a comparable increase in the …

Prototype development of the intelligent hydrogel wound dressing and its efficacy in the detection of model pathogenic wound biofilms

NT Thet, DR Alves, JE Bean, S Booth… - … applied materials & …, 2016 - ACS Publications
The early detection of wound infection in situ can dramatically improve patient care
pathways and clinical outcomes. There is increasing evidence that within an infected wound …

Phytogenically synthesized zinc oxide nanoparticles (ZnO-NPs) potentially inhibit the bacterial pathogens: in vitro studies

M Ahamad Khan, SA Lone, M Shahid, MT Zeyad… - Toxics, 2023 - mdpi.com
The usefulness of nanoparticles (NPs) in biological applications, such as nanomedicine, is
becoming more widely acknowledged. Zinc oxide nanoparticles (ZnO-NPs) are a type of …

Pathogenic arsenal of Pseudomonas aeruginosa: an update on virulence factors

VV Veetilvalappil, A Manuel, JM Aranjani… - Future …, 2022 - Taylor & Francis
The emergence of Pseudomonas aeruginosa as a potential threat in persistent infections
can be attributed to the plethora of virulence factors expressed by it. This review discusses …

An innovative role for luteolin as a natural quorum sensing inhibitor in Pseudomonas aeruginosa

YF Geng, C Yang, Y Zhang, SN Tao, J Mei, XC Zhang… - Life sciences, 2021 - Elsevier
Aims The emergence of antibiotic tolerance was a tricky problem in the treatment of chronic
Pseudomonas aeruginosa-infected cystic fibrosis and burn victims. The quorum sensing …

Impact of phenolic compounds in the acyl homoserine lactone-mediated quorum sensing regulatory pathways

MA Hossain, SJ Lee, NH Park, AF Mechesso… - Scientific Reports, 2017 - nature.com
Quorum sensing (QS) is a cell density-dependent regulation of virulent bacterial gene
expression by autoinducers that potentially pertains in the epidemic of bacterial virulence …

SPaCE Swab: Point-of-Care Sensor for Simple and Rapid Detection of Acute Wound Infection

NT Thet, J Mercer-Chalmers, RJ Greenwood… - ACS …, 2020 - ACS Publications
Wound infection is commonly observed after surgery and trauma but is difficult to diagnose
and poorly defined in terms of objective clinical parameters. The assumption that bacteria in …

Metabolite transporter PEG344 is required for full virulence of hypervirulent Klebsiella pneumoniae strain hvKP1 after pulmonary but not subcutaneous challenge

J Bulger, U MacDonald, R Olson, J Beanan… - Infection and …, 2017 - Am Soc Microbiol
Hypervirulent Klebsiella pneumoniae (hvKP) is an emerging pathotype that is capable of
causing tissue-invasive and organ-and life-threatening infections in healthy individuals from …

Experimental investigation for treating ibuprofen and triclosan by biosurfactant from domestic wastewater

NA Jayalatha, CP Devatha - Journal of Environmental Management, 2023 - Elsevier
The presence of emerging pollutants of pharmaceutical products and personal care
products (PPCPs) in the aquatic environment overspreads the threat on living beings …