Synthetic chromosomes, genomes, viruses, and cells
Synthetic genomics is the construction of viruses, bacteria, and eukaryotic cells with
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …
synthetic genomes. It involves two basic processes: synthesis of complete genomes or …
Bioremediation 3.0: engineering pollutant-removing bacteria in the times of systemic biology
Elimination or mitigation of the toxic effects of chemical waste released to the environment
by industrial and urban activities relies largely on the catalytic activities of microorganisms …
by industrial and urban activities relies largely on the catalytic activities of microorganisms …
Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
The Sc2. 0 project is building a eukaryotic synthetic genome from scratch. A major milestone
has been achieved with all individual Sc2. 0 chromosomes assembled. Here, we describe …
has been achieved with all individual Sc2. 0 chromosomes assembled. Here, we describe …
Candidate phyla radiation, an underappreciated division of the human microbiome, and its impact on health and disease
S Naud, A Ibrahim, C Valles, M Maatouk… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Candidate phyla radiation (CPR) is an emerging division of the bacterial domain within the
human microbiota. Still poorly known, these microorganisms were first described in the …
human microbiota. Still poorly known, these microorganisms were first described in the …
Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration
Chromosome-level design-build-test-learn cycles (chrDBTLs) allow systematic
combinatorial reconfiguration of chromosomes with ease. Here, we established chrDBTL …
combinatorial reconfiguration of chromosomes with ease. Here, we established chrDBTL …
Eliminating a global regulator of carbon catabolite repression enhances the conversion of aromatic lignin monomers to muconate in Pseudomonas putida KT2440
Carbon catabolite repression refers to the preference of microbes to metabolize certain
growth substrates over others in response to a variety of regulatory mechanisms. Such …
growth substrates over others in response to a variety of regulatory mechanisms. Such …
Bacillus subtilis, a swiss army knife in science and biotechnology
ABSTRACT Next to Escherichia coli, Bacillus subtilis is the most studied and best
understood organism that also serves as a model for many important pathogens. Due to its …
understood organism that also serves as a model for many important pathogens. Due to its …
Toward a predictive understanding of Earth's microbiomes to address 21st century challenges
Microorganisms have shaped our planet and its inhabitants for over 3.5 billion years.
Humankind has had a profound influence on the biosphere, manifested as global climate …
Humankind has had a profound influence on the biosphere, manifested as global climate …
Scaling up genetic circuit design for cellular computing: advances and prospects
Synthetic biology aims to engineer and redesign biological systems for useful real-world
applications in biomanufacturing, biosensing and biotherapy following a typical design-build …
applications in biomanufacturing, biosensing and biotherapy following a typical design-build …
Discovery and significance of protein-protein interactions in health and disease
The identification of individual protein-protein interactions (PPIs) began more than 40 years
ago, using protein affinity chromatography and antibody co-immunoprecipitation. As new …
ago, using protein affinity chromatography and antibody co-immunoprecipitation. As new …