Revisiting the neurovascular unit
S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease
C Iadecola - Neuron, 2017 - cell.com
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …
Review Group meeting of the National Institute of Neurological Disorders and Stroke …
Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale
The advent of neuroimaging has increased our understanding of brain function. While most
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …
Brain capillary pericytes exert a substantial but slow influence on blood flow
The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer's disease
To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …
Precapillary sphincters maintain perfusion in the cerebral cortex
Active nerve cells release vasodilators that increase their energy supply by dilating local
blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD …
blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD …
Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response
Fast fMRI enables the detection of neural dynamics over timescales of hundreds of
milliseconds, suggesting it may provide a new avenue for studying subsecond neural …
milliseconds, suggesting it may provide a new avenue for studying subsecond neural …
Brain microvasculature has a common topology with local differences in geometry that match metabolic load
The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …
heterogeneous brain regions. What are common versus heterogeneous aspects of the …