Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease worldwide. The
estimated global incidence of NAFLD is 47 cases per 1,000 population and is higher among …

Type 2 diabetes mellitus (T2DM) is a chronic, complex metabolic disease characterized by
chronic hyperglycemia causing from insufficient insulin signaling because of insulin …

Abstract Purpose of Review Diabetes mellitus (DM) has become a rising epidemic in the last
century, more pressing in the last few decades with the exponential rise of obesity, and has …

Primary liver cancer, the major histology of which is hepatocellular carcinoma (HCC), is the
second leading cause of cancer death worldwide. We comprehensively examined recent …

Abstract The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to
the scientific community about how environmental endocrine-disrupting chemicals (EDCs) …

Diabetic kidney disease–which is defined by elevated urine albumin excretion or reduced
glomerular filtration rate (GFR) or both–is a serious complication that occurs in 20% to 40 …

Obesity is a risk factor for a wide variety of health problems. In a genome-wide association
study (GWAS) of body mass index (BMI) in Japanese people (n= 173,430), we found 85 loci …

Type 2 diabetes is a serious and common chronic disease resulting from a complex
inheritance-environment interaction along with other risk factors such as obesity and …

Maturity-onset diabetes of the young (MODY) is characterized by autosomal dominant
inheritance, onset before 25 years of age, absence of β-cell autoimmunity, and sustained …

Metabolic health depends on the brain's ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone …