Ubiquitination in disease pathogenesis and treatment
D Popovic, D Vucic, I Dikic - Nature medicine, 2014 - nature.com
Ubiquitination is crucial for a plethora of physiological processes, including cell survival and
differentiation and innate and adaptive immunity. In recent years, considerable progress has …
differentiation and innate and adaptive immunity. In recent years, considerable progress has …
The RING finger protein family in health and disease
C Cai, YD Tang, J Zhai, C Zheng - Signal transduction and targeted …, 2022 - nature.com
Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …
Genetics of diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy,
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …
Hydrocarbon stapled peptides as modulators of biological function
Peptide-based drug discovery has experienced a significant upturn within the past decade
since the introduction of chemical modifications and unnatural amino acids has allowed for …
since the introduction of chemical modifications and unnatural amino acids has allowed for …
B-cell receptor signaling in diffuse large B-cell lymphoma
The importance of understanding the genetic and biochemical basis of B-cell receptor (BCR)
survival signaling in diffuse large B-cell lymphoma (DLBCL) is underscored by the recent …
survival signaling in diffuse large B-cell lymphoma (DLBCL) is underscored by the recent …
Linear ubiquitin chains: NF-κB signalling, cell death and beyond
K Iwai, H Fujita, Y Sasaki - Nature reviews Molecular cell biology, 2014 - nature.com
Ubiquitylation is a versatile post-translational modification. Met1-linked linear ubiquitin
chains are involved in nuclear factor-κB signalling and cell death, and dysfunctions in linear …
chains are involved in nuclear factor-κB signalling and cell death, and dysfunctions in linear …
Interpretation of cancer mutations using a multiscale map of protein systems
INTRODUCTION Tumor genome sequencing has revealed that, beyond a few commonly
mutated genes, most mutations that affect cancer genomes are rare. To interpret these rare …
mutated genes, most mutations that affect cancer genomes are rare. To interpret these rare …
Unleashing TNF cytotoxicity to enhance cancer immunotherapy
Tumor necrosis factor (TNF) is a proinflammatory cytokine that is produced and secreted by
cytotoxic lymphocytes upon tumor target recognition. Depending on the context, TNF can …
cytotoxic lymphocytes upon tumor target recognition. Depending on the context, TNF can …
The importance of regulatory ubiquitination in cancer and metastasis
LH Gallo, J Ko, DJ Donoghue - Cell Cycle, 2017 - Taylor & Francis
Ubiquitination serves as a degradation mechanism of proteins, but is involved in additional
cellular processes such as activation of NFκB inflammatory response and DNA damage …
cellular processes such as activation of NFκB inflammatory response and DNA damage …
Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma
To interrogate signaling pathways activated in mantle cell lymphoma (MCL) in vivo, we
contrasted gene expression profiles of 55 tumor samples isolated from blood and lymph …
contrasted gene expression profiles of 55 tumor samples isolated from blood and lymph …