The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Carbonyl stress in red blood cells and hemoglobin

OV Kosmachevskaya, NN Novikova, AF Topunov - Antioxidants, 2021 - mdpi.com
The paper overviews the peculiarities of carbonyl stress in nucleus-free mammal red blood
cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to …

[HTML][HTML] Histidine-Bound Dinitrosyl Iron Complexes: Antioxidant and Antiradical Properties

KB Shumaev, OV Kosmachevskaya… - International Journal of …, 2023 - mdpi.com
Dinitrosyl iron complexes (DNICs) are important physiological derivatives of nitric oxide.
These complexes have a wide range of biological activities, with antioxidant and antiradical …

The effect of hypochlorous acid inhalation on the activity of antioxidant system enzymes in rats of different ages

B Murashevych, H Maslak, D Girenko… - Free Radical …, 2024 - Taylor & Francis
Hypochlorous acid HOCl is an effective disinfectant with a broad spectrum and high rate of
microbicidal action. Its use for air treatment can be an effective tool for the prevention and …

Protective effect of dinitrosyl iron complexes bound with hemoglobin on oxidative modification by peroxynitrite

OV Kosmachevskaya, EI Nasybullina… - International Journal of …, 2021 - mdpi.com
Dinitrosyl iron complexes (DNICs) are a physiological form of nitric oxide (• NO) in an
organism. They are able not only to deposit and transport• NO, but are also to act as …

Effects of Nitrosyl Iron Complexes with Thiol, Phosphate, and Thiosulfate Ligands on Hemoglobin

OV Kosmachevskaya, EI Nasybullina… - International Journal of …, 2024 - mdpi.com
Nitrosyl iron complexes are remarkably multifactorial pharmacological agents. These
compounds have been proven to be particularly effective in treating cardiovascular and …

Effect of iron–nitric oxide complexes on the reactivity of hemoglobin cysteines

OV Kosmachevskaya, EI Nasybullina… - Applied Biochemistry …, 2020 - Springer
Human erythrocyte hemoglobin (Hb) has two reactive cysteines located on the surface of β-
subunits. These cysteines play an important role in the adjustment of Hb functions. It is …

Formation of Supplementary Metal-Binding Centers in Proteins under Stress Conditions

OV Kosmachevskaya, NN Novikova, SN Yakunin… - Biochemistry …, 2024 - Springer
In many proteins, supplementary metal-binding centers appear under stress conditions.
They are known as aberrant or atypical sites. Physico-chemical properties of proteins are …

Effects of glutathione and histidine on NO release from a dimeric dinitrosyl iron complex (DNIC)

DC Pectol, S Khan, M Elsabahy, KL Wooley… - Inorganic …, 2020 - ACS Publications
Rates of NO release from synthetic dinitrosyl iron complexes (DNICs) are shown to be
responsive to coordination environments about iron. The effect of biologically relevant …

The Effect of Peroxynitrite and tert-Butyl Hydroperoxide on Thiol Ligands of Dinitrosyl Iron Complexes

IS Pugachenko, EI Nasybullina… - Applied Biochemistry …, 2023 - Springer
Low-molecular-weight dinitrosyl iron complexes (DNICs) with thiol-containing ligands are a
physiological form for deposit and transport of nitric oxide (NO) in the organism; DNICs can …