The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …

Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine
mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by …

1. INTRODUCTION Epoxide hydrolases have been detected in prokaryotes and eukaryotes
ranging from plants to mammals. 1− 3 In mammals these include the soluble epoxide …

Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active
eicosanoids. The primary epoxidation products are four regioisomers of cis …

In a randomized, double-blinded, controlled clinical trial, participants with peripheral arterial
disease (75% hypertensive) consumed 30 g of milled flaxseed/d for 6 months. The flaxseed …

Early on, intriguing biological activities were found associated with the EETs using in vitro
systems. Although the EETs other than the 5, 6-isomer, are quite stable chemically, they are …