The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not
only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant …

Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in
response to a variety of stimuli to degrade heme, which generates the biologically active …

Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

The aim of this paper is to analyze why ozone can be medically useful when it dissolves in
blood or in other biological fluids. In reviewing a number of clinical studies performed in …

Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and
obesity epidemic. Diabetes and fluctuations of blood sugar are related to multiple micro-and …

Heme oxygenase-1 (HO-1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous
iron. As HO-1 expression is highly increased by stressful conditions, the major role of the …

A common clinical condition, acute kidney injury (AKI) significantly influences morbidity and
mortality, particularly in critically ill patients. The pathophysiology of AKI is complex and …

Abstract Significance: Heme oxygenase-1 (HMOX1) plays a critical role in the protection of
cells, and the inducible enzyme is implicated in a spectrum of human diseases. The …

Aging entails the deterioration of the body's organs, including overall damages at both the
genetic and cellular levels. The prevalence of age-related ocular disease such as macular …