With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

BACKGROUND Conformational changes are essential for the correct functioning of
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …

How do you get into flow? We trained in flow chemistry during postdoctoral research and are
now applying it in new areas: materials chemistry, crystallization, and supramolecular …

The metal centres in metalloenzymes and molecular catalysts are responsible for the
rearrangement of atoms and electrons during complex chemical reactions, and they enable …

In the past decade, 3D printing technologies have been adopted for the fabrication of
microfluidic devices. Extrusion-based approaches including fused filament fabrication (FFF) …

Abstract 3D printing is fast evolving as an additive manufacturing technique that has been
adopted in (bio) analytical science because of the ample variety of materials and …

The current state-of-the-art experiments in time-resolved structural biology are undoubtedly
the recent extremely impressive results that are emerging from XFEL-based experiments …

Careful selection of photocaging approaches is critical to achieve fast and well synchronized
reaction initiation and perform successful time-resolved structural biology experiments. This …

X-ray crystallography enables detailed structural studies of proteins to understand and
modulate their function. Conducting crystallographic experiments at cryogenic temperatures …

The use of microfluidics on synchrotron X-ray beamlines represents an advanced sample
preparation and delivery platform for state-of-the-art X-ray characterization of micro-samples …