Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors
S Dallavalle, V Dobričić, L Lazzarato, E Gazzano… - Drug Resistance …, 2020 - Elsevier
Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy.
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …
Design, development, in silico and in vitro characterization of Docetaxel-loaded TPGS/Pluronic F 108 mixed micelles for improved cancer treatment
Background Docetaxel (DTX) has been used to treat numerous types of cancers. It's poor
solubility, serious side effects, and multi-drug resistance (MDR) limits its use in cancer …
solubility, serious side effects, and multi-drug resistance (MDR) limits its use in cancer …
Pluronic micelles with suppressing doxorubicin efflux and detoxification for efficiently reversing breast cancer resistance
X Cheng, X Lv, J Xu, Y Zheng, X Wang… - European Journal of …, 2020 - Elsevier
The antitumor activity of doxorubicin (DOX) is often limited owing to the occurrence of
multidrug resistance (MDR) during treatment. Herein, we developed hybrid polymeric …
multidrug resistance (MDR) during treatment. Herein, we developed hybrid polymeric …
Podophyllotoxin-polyacrylic acid conjugate micelles: improved anticancer efficacy against multidrug-resistant breast cancer
Background Podophyllotoxin (PPT) is a naturally occurring compound obtained from the
roots of Podophyllum species, indicated for a variety of malignant tumors such as breast …
roots of Podophyllum species, indicated for a variety of malignant tumors such as breast …
Development and validation of RP-HPLC method for simultaneous estimation of docetaxel and ritonavir in PLGA nanoparticles
Objectives The main objective of the present study was to develop and validate simple,
precise, sensitive and accurate RP-HPLC method for the simultaneous estimation of …
precise, sensitive and accurate RP-HPLC method for the simultaneous estimation of …
Design, development, in silico, and in vitro characterization of camptothecin-loaded mixed micelles: in vitro testing of verapamil and ranolazine for repurposing as …
Purpose Camptothecin has poor solubility, high systemic toxicity, and intrinsic structural
instability. To deal with these challenges, present research aimed to develop camptothecin …
instability. To deal with these challenges, present research aimed to develop camptothecin …
[HTML][HTML] Antidiabetic and antihyperlipidemic effects of Argyreia pierreana and Matelea denticulata: Higher activity of the micellar nanoformulation over the crude extract
V Gudise, B Chowdhury, AS Manjappa - Journal of Traditional and …, 2021 - Elsevier
Background and aim Herbal medicine combined with nanotechnology is widely proposed to
improve the oral bioavailability, reduce the required dose and side effects, and improve the …
improve the oral bioavailability, reduce the required dose and side effects, and improve the …
Development of docetaxel-loaded (Soluplus®–PF108) mixed micelles vacuum foam-dried product for improved stability and melanoma treatment by QbD approach
Background Docetaxel (DTX) finds extensive use in treating various cancers, but its limited
solubility, side effects, and multi-drug resistance (MDR) hinder its effectiveness. To enhance …
solubility, side effects, and multi-drug resistance (MDR) hinder its effectiveness. To enhance …
A remarkable in vitro cytotoxic, cell cycle arresting and proapoptotic characteristics of low-dose mixed micellar simvastatin combined with alendronate sodium
The objective of the present study was to screen the effect of increased simvastatin (SVS)
solubility, through mixed micelles as a model approach, on in vitro anticancer efficacy in …
solubility, through mixed micelles as a model approach, on in vitro anticancer efficacy in …
Ameliorated in vitro anticancer efficacy of methotrexate d-α-Tocopheryl polyethylene glycol 1000 succinate ester against breast cancer cells
Background Methotrexate (MTX), a folate anti-metabolite, has been used widely in the
treatment of plenty of malignancies. However, the clinical use is limited because of its poor …
treatment of plenty of malignancies. However, the clinical use is limited because of its poor …