Radioactive main group and rare earth metals for imaging and therapy

TI Kostelnik, C Orvig - Chemical reviews, 2018 - ACS Publications
Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry

A Mucha, P Kafarski, Ł Berlicki - Journal of Medicinal Chemistry, 2011 - ACS Publications
R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

Prospective of 68Ga-radiopharmaceutical development

I Velikyan - Theranostics, 2013 - pmc.ncbi.nlm.nih.gov
Positron Emission Tomography (PET) experienced accelerated development and has
become an established method for medical research and clinical routine diagnostics on …

Clinical applications of Gallium-68

SR Banerjee, MG Pomper - Applied Radiation and Isotopes, 2013 - Elsevier
Gallium-68 is a positron-emitting radioisotope that is produced from a 68Ge/68Ga generator.
As such it is conveniently used, decoupling radiopharmacies from the need for a cyclotron …

Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling

MI Tsionou, CE Knapp, CA Foley, CR Munteanu… - RSC …, 2017 - pubs.rsc.org
Gallium-68 (68Ga) is a positron-emitting isotope used for clinical PET imaging of peptide
receptor expression. 68Ga radiopharmaceuticals used in molecular PET imaging consist of …

Tumour targeting with radiometals for diagnosis and therapy

CF Ramogida, C Orvig - Chemical Communications, 2013 - pubs.rsc.org
Use of radiometals in nuclear oncology is a rapidly growing field and encompasses a broad
spectrum of radiotracers for imaging via PET (positron emission tomography) or SPECT …

Past, present and future of 68Ge/68Ga generators

F Rösch - Applied Radiation and Isotopes, 2013 - Elsevier
68Ga represents one of the very early radionuclides applied to positron emission
tomography (PET) imaging at a time when even the wording PET itself was not established …

The renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in 68Ga radiopharmaceutical chemistry

F Roesch, P J. Riss - Current topics in medicinal chemistry, 2010 - benthamdirect.com
68Ge/68Ga radionuclide generators have been investigated for almost fifty years now, since
the cyclotronindependent availability of positron emitting 68Ga via the 68Ge/68Ga system …

Bifunctional gallium-68 chelators: Past, present, and future

P Spang, C Herrmann, F Roesch - Seminars in nuclear medicine, 2016 - Elsevier
This article reviews the development of bifunctional chelates for synthesising 68 Ga
radiopharmaceuticals. It structures the chelates into groups of macrocycles …