Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Populations of tumour cells display remarkable variability in almost every discernable
phenotypic trait, including clinically important phenotypes such as ability to seed metastases …

Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current
cell-type classification system. However, a transcriptome-based single-cell atlas has not …

Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Emerging methods for the accurate quantification of gene expression in individual cells hold
promise for revealing the extent, function and origins of cell-to-cell variability. Different high …

Detection of somatic point substitutions is a key step in characterizing the cancer genome.
However, existing methods typically miss low-allelic-fraction mutations that occur in only a …

Most known pathogenic point mutations in humans are C• G to T• A substitutions, which can
be directly repaired by adenine base editors (ABEs). In this study, we investigated the …

The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life
is associated with various age-related diseases, including cancer,. Extreme variation in …

Recent therapeutic advances in oncology have been driven by the identification of tumour
genotype variations between patients, called interpatient heterogeneity, that predict the …

Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but
provide limited insight into the genomic diversity within tumours. Here we developed a …