Across all settings, women self-report more drug allergies than do men. Although there is
epidemiologic evidence of increased drug allergy labeling in postpubertal females, the …

MRGPRX2, a novel Gaq‐coupled human mast cell receptor, mediates non‐immune adverse
reactions without the involvement of antibody priming. Constitutively expressed by human …

Since the seminal description implicating occupation of the Mas-related G protein-coupled
receptor X2 (MRGPRX2) in mast cell (MC) degranulation by drugs, many investigations …

Immediate drug-induced hypersensitivity reactions (IDHSRs) have conventionally been
attributed to an immunoglobulin E (IgE)–mediated mechanism. Nevertheless, it has now …

Mast cells (MCs) are bone-marrow-derived haematopoietic cells that are widely distributed
in human tissues. When activated, they will release tryptase, histamine and other mediators …

To the Editor, Gadolinium-based contrast agents (GBCA) are intravenous drugs used to
enhance resolution in magnetic resonance imaging. They can induce immediate …

Mas-related G-protein-coupled receptor X2 (MRGPRX2), expressed on mast cells, is
associated with drug-induced pseudo-allergic reactions. Although it is well known that there …

Background Vancomycin infusion reaction (VIR), reportedly mediated through Mas-Related
G Protein–Coupled Receptor-X2, is the primary vancomycin-induced immediate drug …

The implementation of existing guidelines which consensually recommend paired tryptase
measurement is a persistent unmet need hampering optimal diagnosis of drug-induced …

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