The role of microenvironment in tumor angiogenesis
X Jiang, J Wang, X Deng, F **ong, S Zhang… - Journal of Experimental …, 2020 - Springer
Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …
and plays an important role in their growth, invasion, and metastasis. The tumor …
Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis
K Ghoreschi, A Balato, C Enerbäck, R Sabat - The Lancet, 2021 - thelancet.com
Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …
IL-1 family cytokine regulation of vascular permeability and angiogenesis
E Fahey, SL Doyle - Frontiers in Immunology, 2019 - frontiersin.org
The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory
responses both in response to and acting as danger signals. It has long been established …
responses both in response to and acting as danger signals. It has long been established …
Keratinocyte: A trigger or an executor of psoriasis?
X Ni, Y Lai - Journal of Leucocyte Biology, 2020 - academic.oup.com
Psoriasis is a common chronic inflammatory skin disease characterized by abnormal
proliferation/differentiation of keratinocytes and excessive immune cell infiltration in the …
proliferation/differentiation of keratinocytes and excessive immune cell infiltration in the …
Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration
Macrophage has been gradually recognized as a central regulator in tissue regeneration,
and the study of how macrophage mediates biomaterials-induced bone regeneration …
and the study of how macrophage mediates biomaterials-induced bone regeneration …
[HTML][HTML] Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions
KL Sachen, CNA Greving, JE Towne - Cytokine, 2022 - Elsevier
The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and
IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric …
IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric …
Role of the IL-23/IL-17 axis in psoriasis and psoriatic arthritis: the clinical importance of its divergence in skin and joints
Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …
The significance of IL-36 hyperactivation and IL-36R targeting in psoriasis
S Madonna, G Girolomoni, CA Dinarello… - International journal of …, 2019 - mdpi.com
Psoriasis is an immune-mediated inflammatory skin disease that involves mainly T helper
(Th) 17, Th1 and Th22 lymphocytes, which cause hyper-proliferation of the epidermis with …
(Th) 17, Th1 and Th22 lymphocytes, which cause hyper-proliferation of the epidermis with …
Targeting IL-36 in inflammatory skin diseases
R Fukaura, M Akiyama - BioDrugs, 2023 - Springer
Abstract Interleukin (IL)-36 cytokines are members of the IL-1 superfamily of cytokines. IL-36
cytokines are composed of three agonists (IL-36α, IL-36β, and IL-36γ) and two antagonists …
cytokines are composed of three agonists (IL-36α, IL-36β, and IL-36γ) and two antagonists …
Exploring the role of IL-36 cytokines as a new target in psoriatic disease
Unmet needs in the treatment of psoriasis call for novel therapeutic strategies. Pustular
psoriasis and psoriatic arthritis often represent a therapeutic challenge. Focus on IL-36 …
psoriasis and psoriatic arthritis often represent a therapeutic challenge. Focus on IL-36 …