The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
Rats and mice are attracted by novel objects. They readily approach novel objects and
explore them with their vibrissae, nose and forepaws. It is assumed that such a single …
explore them with their vibrissae, nose and forepaws. It is assumed that such a single …
The serotonergic system in ageing and Alzheimer's disease
Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates
cognitive functions and primarily affects associated brain regions involved in learning and …
cognitive functions and primarily affects associated brain regions involved in learning and …
Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms …
A de Bartolomeis, L Vellucci, A Barone… - Pharmacology & …, 2022 - Elsevier
Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …
The monoaminergic system is a bilaterian innovation
M Goulty, G Botton-Amiot, E Rosato… - Nature …, 2023 - nature.com
Monoamines like serotonin, dopamine, and adrenaline/noradrenaline (epinephrine/
norepinephrine) act as neuromodulators in the nervous system. They play a role in complex …
norepinephrine) act as neuromodulators in the nervous system. They play a role in complex …
Role of cholesterol in the function and organization of G-protein coupled receptors
Cholesterol is an essential component of eukaryotic membranes and plays a crucial role in
membrane organization, dynamics and function. The modulatory role of cholesterol in the …
membrane organization, dynamics and function. The modulatory role of cholesterol in the …
[HTML][HTML] Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function
Like all other monomeric or multimeric transmembrane proteins, receptors for
neurotransmitters are surrounded by a shell of lipids which form an interfacial boundary …
neurotransmitters are surrounded by a shell of lipids which form an interfacial boundary …
Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking
Serotonin receptors 5-HT1A and 5-HT7 are highly coexpressed in brain regions implicated
in depression. However, their functional interaction has not been established. In the present …
in depression. However, their functional interaction has not been established. In the present …
A molecular sensor for cholesterol in the human serotonin1A receptor
The function of several G protein–coupled receptors (GPCRs) exhibits cholesterol sensitivity.
Cholesterol sensitivity of GPCRs could be attributed to specific sequence and structural …
Cholesterol sensitivity of GPCRs could be attributed to specific sequence and structural …
[HTML][HTML] Molecular dynamics simulations of GPCR–cholesterol interaction: An emerging paradigm
G protein-coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …
transduction across cell membranes and represent major targets in the development of …
Membrane cholesterol in the function and organization of G-protein coupled receptors
Cholesterol is an essential component of higher eukaryotic membranes and plays a crucial
role in membrane organization, dynamics and function. The G-protein coupled receptors …
role in membrane organization, dynamics and function. The G-protein coupled receptors …