The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …

Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely
used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 …

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

Members of sirtuin family regulate multiple critical biological processes, yet their role in
carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in …

Neuronal activity is a high‐energy demanding process recruiting all neural cells that adapt
their metabolism to sustain the energy and redox balance of neurons. During …

Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of
anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial …

A great many cell types are necessary for the myriad capabilities of complex, multicellular
organisms. One interesting aspect of this diversity of cell type is that many cells in diploid …