Targeting misfolding and aggregation of the amyloid-β peptide and mutant p53 protein using multifunctional molecules

L Grcic, G Leech, K Kwan, T Storr - Chemical Communications, 2024 - pubs.rsc.org
Biomolecule misfolding and aggregation play a major role in human disease, spanning from
neurodegeneration to cancer. Inhibition of these processes is of considerable interest, and …

Metal–BODIPY complexes: versatile photosensitizers for oxidizing amyloid-β peptides and modulating their aggregation profiles

M Kim, G Gupta, J Lee, C Na, J Kwak, Y Lin… - Inorganic Chemistry …, 2024 - pubs.rsc.org
Photodynamic therapy (PDT) holds significant promise as a medical treatment approach in
human diseases. Recently, PDT has received attention to harness light-induced reactive …

[HTML][HTML] Unveiling the effects of copper ions in the aggregation of amyloidogenic proteins

V Oliveri - Molecules, 2023 - mdpi.com
Amyloid diseases have become a global concern due to their increasing prevalence.
Transition metals, including copper, can affect the aggregation of the pathological proteins …

Leuco Ethyl Violet as Self‐Activating Prodrug Photocatalyst for In Vivo Amyloid‐Selective Oxygenation

M Furuta, S Arii, H Umeda, R Matsukawa… - Advanced …, 2024 - Wiley Online Library
Aberrant aggregates of amyloid‐β (Aβ) and tau protein (tau), called amyloid, are related to
the etiology of Alzheimer disease (AD). Reducing amyloid levels in AD patients is a …

Detection and disaggregation of amyloid fibrils by luminescent amphiphilic platinum (II) complexes

Z Li, AB Ekanayake, AE Bartman, JA Doorn… - Dalton …, 2024 - pubs.rsc.org
Cyclometallated Pt (II) complexes possessing hydrophobic 2-phenylpyridine (ppy) ligands
and hydrophilic acetonylacetone (acac) ligands have been investigated for their ability to …

2-Phenylbenzothiazolyl iridium complexes as inhibitors and probes of amyloid β aggregation

K Terpstra, Y Huang, H Na, L Sun, C Gutierrez… - Dalton …, 2024 - pubs.rsc.org
The aggregation of amyloid β (Aβ) peptides is a significant hallmark of Alzheimer's disease
(AD), and the detection of Aβ aggregates and the inhibition of their formation are important …

Multi-target macrocycles: pyrogallol derivatives to control multiple pathological factors associated with Alzheimer's disease

J Kwak, Y Yi, S Park, MH Lim - Chemical Science, 2025 - pubs.rsc.org
Designing multi-target chemical tools is a vital approach to understanding the pathology of
Alzheimer's disease (AD), which involves a complex network of pathological factors, such as …

Ruthenium (II) Polypyridyl Complexes with Benzoxazole Derivatives and Non‐Innocent Ligands as Effective Antioxidants in Human Neuroblasts

GE Giacomazzo, L Conti, D Paderni… - … A European Journal, 2024 - Wiley Online Library
Ruthenium (II) polypyridyl complexes continue to raise increasing interest for the
encouraging results in several biomedical areas. Considering their vast chemical‐physical …

Investigation of Functionalized (2-Phenylpyridine) Pt (II) Complexes for Monitoring and Interfering With Amyloid Aggregation

Z Li - 2024 - search.proquest.com
Several diseases (eg Alzheimer's disease (AD)) are characterized by formation of cytotoxic
amyloid oligomers and fibrils. Consequently, methods to detect and monitor amyloid …