2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

B Pajak, E Siwiak, M Sołtyka, A Priebe… - International journal of …, 2019 - mdpi.com
The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates
that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and …

Sonodynamic therapy-derived multimodal synergistic cancer therapy

M Xu, L Zhou, L Zheng, Q Zhou, K Liu, Y Mao, S Song - Cancer letters, 2021 - Elsevier
Sonodynamic therapy (SDT) represents a promising modality that provides the possibility of
non-invasively eliminating solid tumors in a site-directed manner. In light of the complexity …

Inorganic nanoparticles: a potential cancer therapy for human welfare

A Pugazhendhi, TNJI Edison, I Karuppusamy… - International journal of …, 2018 - Elsevier
Cancer is an abnormal condition leading to uncontrolled cell division which causes damage
to the body tissues. Around 100 types of cancer are studied so far namely breast cancer …

Drug tolerant persister cell plasticity in cancer: A revolutionary strategy for more effective anticancer therapies

J He, Z Qiu, J Fan, X **e, Q Sheng, X Sui - Signal transduction and …, 2024 - nature.com
Non-genetic mechanisms have recently emerged as important drivers of anticancer drug
resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more …

Targeting the ROS/PI3K/AKT/HIF‐1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2‐Deoxy‐d‐glucose

T Zhang, X Zhu, H Wu, K Jiang, G Zhao… - Journal of Cellular …, 2019 - Wiley Online Library
It is well established that cancer cells depend upon aerobic glycolysis to provide the energy
they need to survive and proliferate. However, anti‐glycolytic agents have yielded few …

2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation

X Sun, T Fan, G Sun, Y Zhou, Y Huang, N Zhang… - Biochemical …, 2022 - Elsevier
Chloroethylnitrosoureas (CENUs) exert antitumor activity via producing dG-dC interstrand
crosslinks (ICLs). However, tumor resistance make it necessary to find novel strategies to …

2‐Deoxy‐D‐Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence‐Lowering in Covid‐19, and Other Pharmacological …

R Singh, V Gupta, A Kumar… - … in Pharmacological and …, 2023 - Wiley Online Library
The nonmetabolizable glucose analog 2‐deoxy‐D‐glucose (2‐DG) has shown promising
pharmacological activities, including inhibition of cancerous cell growth and N …

2‐Deoxy‐D‐glucose simultaneously targets glycolysis and Wnt/β‐catenin signaling to inhibit cervical cancer progression

M Su, S Shan, Y Gao, M Dai, H Wang, C He… - IUBMB …, 2023 - Wiley Online Library
Cervical cancer is one of the most common female malignant tumors, with typical cancer
metabolism characteristics of increased glycolysis flux and lactate accumulation. 2‐Deoxy‐D …

Sonodynamic therapy combined to 2-deoxyglucose potentiate cell metastasis inhibition of breast cancer

L **e, X Feng, M Huang, K Zhang, Q Liu - Ultrasound in medicine & biology, 2019 - Elsevier
Metastasis is a major dilemma of cancer therapy. It frequently occurs in breast cancer, which
is the leading form of malignant tumor among females worldwide. Although there are …

Multi-targeted approach by 2-benzimidazolylquinoxalines-loaded cationic arginine liposomes against сervical cancer cells in vitro

TN Pashirova, NA Zhukova, SS Lukashenko… - Colloids and Surfaces B …, 2019 - Elsevier
Multi-targeted approaches for inhibition of сervical cancer cells in vitro were developed by
implementing two different strategies and drug combination for creation of new therapeutic …