Development and use of machine learning algorithms in vaccine target selection
B Bravi - npj Vaccines, 2024 - nature.com
Computer-aided discovery of vaccine targets has become a cornerstone of rational vaccine
design. In this article, I discuss how Machine Learning (ML) can inform and guide key …
design. In this article, I discuss how Machine Learning (ML) can inform and guide key …
Structure-based methods for binding mode and binding affinity prediction for peptide-MHC complexes
Understanding the mechanisms involved in the activation of an immune response is
essential to many fields in human health, including vaccine development and personalized …
essential to many fields in human health, including vaccine development and personalized …
Structural dissimilarity from self drives neoepitope escape from immune tolerance
JR Devlin, JA Alonso, CM Ayres, GLJ Keller… - Nature chemical …, 2020 - nature.com
T-cell recognition of peptides incorporating nonsynonymous mutations, or neoepitopes, is a
cornerstone of tumor immunity and forms the basis of new immunotherapy approaches …
cornerstone of tumor immunity and forms the basis of new immunotherapy approaches …
Immunogenic T cell epitopes of SARS-CoV-2 are recognized by circulating memory and naïve CD8 T cells of unexposed individuals
Background Recent studies have provided evidence of T cell reactivity to Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected …
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected …
PANDORA: a fast, anchor-restrained modelling protocol for peptide: MHC complexes
Deeper understanding of T-cell-mediated adaptive immune responses is important for the
design of cancer immunotherapies and antiviral vaccines against pandemic outbreaks. T …
design of cancer immunotherapies and antiviral vaccines against pandemic outbreaks. T …
HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes
The class I proteins of the major histocompatibility complex (MHC-I) display epitopic
peptides derived from endogenous proteins on the cell surface for immune surveillance …
peptides derived from endogenous proteins on the cell surface for immune surveillance …
Uncovering the tumor antigen landscape: what to know about the discovery process
According to the latest available data, cancer is the second leading cause of death,
highlighting the need for novel cancer therapeutic approaches. In this context …
highlighting the need for novel cancer therapeutic approaches. In this context …
APE-Gen2. 0: Expanding Rapid Class I Peptide–Major Histocompatibility Complex Modeling to Post-Translational Modifications and Noncanonical Peptide …
The recognition of peptides bound to class I major histocompatibility complex (MHC-I)
receptors by T-cell receptors (TCRs) is a determinant of triggering the adaptive immune …
receptors by T-cell receptors (TCRs) is a determinant of triggering the adaptive immune …
Viral molecular mimicry influences the antitumor immune response in murine and human melanoma
Molecular mimicry is one of the leading mechanisms by which infectious agents can induce
autoimmunity. Whether a similar mechanism triggers an antitumor immune response is …
autoimmunity. Whether a similar mechanism triggers an antitumor immune response is …
Interpreting T-cell cross-reactivity through structure: implications for TCR-based cancer immunotherapy
Immunotherapy has become one of the most promising avenues for cancer treatment,
making use of the patient's own immune system to eliminate cancer cells. Clinical trials with …
making use of the patient's own immune system to eliminate cancer cells. Clinical trials with …