Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …

Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …

The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …

Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …

Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …

Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …

The “tail approach” has become a milestone in human carbonic anhydrase inhibitor (hCAI)
design for various therapeutics, including antiglaucoma agents. Besides the classical …

Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …

Enzyme inhibition is a commonly utilized method for controlling enzymatic activity in various
physiologically relevant biological systems. Herein, the selected five active antiviral drugs …

Glaucoma, a leading cause of irreversible vision loss worldwide, is characterized by
elevated intraocular pressure (IOP), a well-established risk factor across all its forms. We …