Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles
rich in calcium and polyphosphate, are the only organelles that have been conserved during …

Trypanosoma brucei provides an excellent system for studies of many aspects of cell
biology, including cell structure and morphology, organelle positioning, cell division and …

The 9+ 2 microtubule axoneme of flagella and cilia represents one of the most iconic
structures built by eukaryotic cells and organisms. Both unity and diversity are present …

Trypanosoma brucei is a pathogenic unicellular eukaryote that infects humans and other
mammals in sub-Saharan Africa. A central feature of trypanosome biology is the single …

Trypanosomes are important disease agents and excellent models for the study of
evolutionary cell biology. The trypanosome flagellar pocket is a small invagination of the …

Flagella and cilia are elaborate cytoskeletal structures conserved from protists to mammals,
where they fulfil functions related to motility or sensitivity. Here we demonstrate novel roles …

Background The transition from prokaryotes to eukaryotes was the most radical change in
cell organisation since life began, with the largest ever burst of gene duplication and novelty …

Centrioles are self-reproducing organelles that form the core structure of centrosomes or
microtubule-organizing centers (MTOCs). However, whether duplication and MTOC …

This study uses electron tomography linked to a variety of other EM methods to provide an
integrated view of the flagellar pocket and basal body area of the African trypanosome …

Intraflagellar transport (IFT) is the bidirectional movement of protein complexes required for
cilia and flagella formation. We investigated IFT by analyzing nine conventional IFT genes …