Nature produces a variety of different species, prokaryotes and eukaryotes. Among them,
fungi play a very important, but yet mostly unexplored role. Their widespread occurrence on …

The biological activity of mycotoxins ranges from weak and/or sometimes positive effects,
such as antibacterial activity (see penicillin derivatives derived from Penicillium strains) to …

Abstract Two new 2-benzylpyridin-4-one containing metabolites, aspernigrins C (3) and D
(4), together with six known compounds (1, 2, and 5–8), were isolated from the marine …

Disulfide-bridged peptide bicycles (DBPBs) are molecules that contain a transannular
disulfide bridge within a macrocyclic framework. While DBPBs are precedented in nature …

A general strategy is introduced for the efficient synthetic access of disulfide linked artificial
macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization …

Malformin C, a fungal cyclic pentapeptide, has been claimed to have anti-cancer potential,
but no in vivo study was available to substantiate this property. Therefore, we conducted in …

Abstract The ICH S6 (R1) recommendations on safety evaluation of biotherapeutics have led
to uncertainty in determining what would constitute a cause for concern that would require …

Acquired immunodeficiency syndrome (AIDS) caused by human immunodeficiency virus
(HIV) infection is a serious public problem threatening global health. At present, although …

Macrocycles possess desirable properties that make them promising candidates for the
discovery of novel drugs. They present structural features to favor bioactive conformations …

We accomplished the solid-phase total synthesis of malformin C, which is adaptable for the
easy preparation of various derivatives. A solid-phase total synthesis of malformin C was …