The continued westward dissemination of H5N1 influenza A viruses in avian populations
and the nearly 50% mortality rate of humans infected with H5N1 are a source of great …

The hemagglutinin (HA) is a prime determinant of the pathogenicity of influenza A viruses. It
initiates infection by binding to cell surface receptors and by inducing membrane fusion. The …

Human influenza virus rapidly accumulates mutations in its major surface protein
hemagglutinin (HA). The evolutionary success of influenza virus lineages depends on how …

Influenza is notable for its evolutionary capacity to escape immunity targeting the viral
hemagglutinin. We used deep mutational scanning to examine the extent to which a high …

Worldwide, acute respiratory infections (ARIs) constitute the leading cause of acute
illnesses, being responsible for nearly 4million deaths every year, mostly in young children …

There is an unmet public health need for a universal influenza vaccine (UIV) to provide
broad and durable protection from influenza virus infections. The identification of broadly …

Many viruses interact with the host cell division cycle to favor their own growth. In this study,
we examined the ability of influenza A virus to manipulate cell cycle progression. Our results …

Commercial vaccines currently available against swine influenza virus (SIV) are inactivated,
adjuvanted, whole virus vaccines, based on H1N1 and/or H3N2 and/or H1N2 SIVs. In …

Technological advances in immunology, protein design, and genetic delivery have unlocked
new possibilities for vaccine concepts and delivery technologies that were previously …

Swine Influenza A Virus (IAV-S) imposes a significant impact on the pork industry and has
been deemed a significant threat to global public health due to its zoonotic potential. The …