Recent evidence shows that when ischemic stroke (IS) occurs, the BBB would be destructed,
thereby promoting the immune cells to migrate into the brain, suggesting that the immune …

Data from basic science experiments is overwhelmingly supportive of the causal role of
immune‐inflammatory response (s) at the core of atherosclerosis, and therefore, the …

We have interrogated a 12-chemokine gene expression signature (GES) on genomic arrays
of 14,492 distinct solid tumors and show broad distribution across different histologies. We …

We hypothesized that immune gene-related signatures would predict the presence of
unique histological features of lymphoid cell infiltrates in colorectal carcinoma (CRC) that …

Both innate and adaptive mechanisms participate in the pathogenesis of kidney ischemia-
reperfusion injury (IRI), but the role of regulatory immune mechanisms is unknown. We …

Ongoing research continues to strengthen the case that statins can modulate immune
responses by several mechanisms, independent of lowering blood cholesterol. A major …

Statins were first identified over 40 years ago as lipid-lowering drugs and have been
remarkably effective in treating cardiovascular diseases. As research advanced, the …

Background A growing number of studies found inconsistent results on the role of
chemokines in the progression of type 2 diabetes (T2DM) and prediabetes (PDM). The …

The pleiotropic effects of statins have been evaluated to assess their potential benefit in the
treatment of various inflammatory and immune‐mediated diseases including periodontitis …

Drugs used for therapeutic interventions either alone or in combination may sometimes
cause unexpected toxicity to the muscles, resulting in a varying degree of symptomatology …