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Advances in sarcoma genomics and new therapeutic targets
Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …
Uterine leiomyosarcoma: Epidemiology, contemporary treatment strategies and the impact of uterine morcellation
Leiomyosarcoma, a rare tumor subtype, accounts for 1% of all uterine malignancies, but
contributes to a significant proportion of uterine cancer deaths. Surgery is considered the …
contributes to a significant proportion of uterine cancer deaths. Surgery is considered the …
B cells are associated with survival and immunotherapy response in sarcoma
Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50
histological subtypes,. The clinical presentation of patients with different subtypes is often …
histological subtypes,. The clinical presentation of patients with different subtypes is often …
Comprehensive and integrated genomic characterization of adult soft tissue sarcomas
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …
Comprehensive and integrated genomic characterization of adult soft tissue sarcomas
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …
Response to anti-PD1 therapy with nivolumab in metastatic sarcomas
L Paoluzzi, A Cacavio, M Ghesani… - Clinical sarcoma …, 2016 - Springer
Background Manipulation of immune checkpoints such as CTLA4 or PD-1 with targeted
antibodies has recently emerged as an effective anticancer strategy in multiple …
antibodies has recently emerged as an effective anticancer strategy in multiple …
Doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, or doxorubicin alone as a first‐line treatment for advanced leiomyosarcoma: a propensity score matching …
L D'Ambrosio, N Touati, JY Blay, G Grignani… - Cancer, 2020 - Wiley Online Library
Background The optimal treatment for advanced leiomyosarcoma is still debated. Given
histotype‐specific prospective controlled data lacking, this study retrospectively evaluated …
histotype‐specific prospective controlled data lacking, this study retrospectively evaluated …
Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma
Antibodies against CD47, which block tumor cell CD47 interactions with macrophage signal
regulatory protein-α, have been shown to decrease tumor size in hematological and …
regulatory protein-α, have been shown to decrease tumor size in hematological and …
TP53 in bone and soft tissue sarcomas
Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …
Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer
HJ Lim, P Crowe, JL Yang - Journal of cancer research and clinical …, 2015 - Springer
Purpose PTEN is an essential tumour suppressor gene which encodes a phosphatase
protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this …
protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this …