The success of chimeric antigen receptor (CAR) T cells targeting B-cell malignancies
propelled the field of synthetic immunology and raised hopes to treat solid tumors in a …

The tumor-killing properties of T cells provide tremendous opportunities to treat cancer.
Adoptive T cell therapies have begun to harness this potential by endowing a functionally …

Calorie restriction increases life span in many organisms, including the budding yeast
Saccharomyces cerevisiae. From a large-scale analysis of 564 single-gene–deletion strains …

Interactions between B and T cells are essential for most antibody responses, but the
dynamics of these interactions are poorly understood. By two-photon microscopy of intact …

A notable feature of T lymphocyte recognition on other cell surfaces is the formation of a
stable mature immunological synapse. Here we use a single-molecule labeling method to …

The immunological synapse is a specialized cell-cell junction that is defined by large-scale
spatial patterns of receptors and signaling molecules yet remains largely enigmatic in terms …

The binding of a T-cell antigen receptor (TCR) to peptide antigen presented by major
histocompatibility antigens (pMHC) on antigen-presenting cells (APCs) is a central event in …

The TCR can detect subtle differences in the strength of interaction with peptide/MHC ligand
and transmit this information to influence downstream events in T cell responses …

Analogue peptides with enhanced binding affinity to major histocompatibility class (MHC) I
molecules are currently being used in cancer patients to elicit stronger T cell responses …

γδ T cells present in epithelial tissues provide a crucial first line of defense against
environmental insults, including infection, trauma, and malignancy, yet the molecular events …