Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …

Stroke is a heterogeneous syndrome, and determining risk factors and treatment depends
on the specific pathogenesis of stroke. Risk factors for stroke can be categorized as …

Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Proteins circulating in the blood are critical for age-related disease processes; however, the
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …

Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Background: Seed-based studies on resting-state functional connectivity (rsFC) in
schizophrenia have shown disrupted connectivity involving a number of brain networks; …

Population-based prospective studies, such as UK Biobank, are valuable for generating and
testing hypotheses about the potential causes of human disease. We describe how UK …

Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …