Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
CD Fuchs, M Trauner - Nature reviews Gastroenterology & hepatology, 2022 - nature.com
Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …
Therapeutic pipeline in nonalcoholic steatohepatitis
Our understanding of nonalcoholic fatty liver disease pathophysiology continues to advance
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …
rapidly. Accordingly, the field has moved from describing the clinical phenotype through the …
EASL Clinical Practice Guidelines on sclerosing cholangitis
Management of primary or secondary sclerosing cholangitis is challenging. These Clinical
Practice Guidelines have been developed to provide practical guidance on debated topics …
Practice Guidelines have been developed to provide practical guidance on debated topics …
Molecular physiology of bile acid signaling in health, disease, and aging
A Perino, H Demagny… - Physiological …, 2021 - journals.physiology.org
Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …
AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …
Bile acids and their receptors in metabolic disorders
Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …
Novel therapeutic targets for cholestatic and fatty liver disease
M Trauner, CD Fuchs - Gut, 2022 - gut.bmj.com
Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …
Discovery of farnesoid X receptor and its role in bile acid metabolism
In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …
[HTML][HTML] Farnesoid X receptor (FXR): Structures and ligands
L Jiang, H Zhang, D **ao, H Wei, Y Chen - Computational and structural …, 2021 - Elsevier
Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …