Esophageal cancer is a unique and complex heterogeneous malignancy, with substantial
tumor heterogeneity: at the cellular levels, tumors are composed of tumor and stromal …

The advancement of RNAseq and isoform-specific expression platforms has led to the
understanding that isoform changes can alter molecular signaling to promote tumorigenesis …

Recent studies have suggested that ubiquitin-conjugating enzyme E2D1 (UBE2D1) is
involved in tumor progression. In this study, we found that UBE2D1 expression was …

Immunosuppression is a common feature of esophageal adenocarcinoma (EAC) and has
been linked to poor overall survival (OS). We hypothesized that upstream factors might …

Abstract Frequent (> 70%) TP53 mutations often promote its protein stabilization, driving
esophageal adenocarcinoma (EAC) development linked to poor survival and therapy …

Glioblastoma (GBM) cells exhibit aberrant proliferative abilities and resistance to
conventional therapies. However, the mechanisms underlying these malignant phenotypes …

Background and Objectives: Temperature-sensitive (TS) mutants of TP53 are thermally
unstable, unfolded, and inactive at body temperature but can be refolded and reactivated at …

Colorectal cancer has the third highest incidence and second highest mortality rate among
all cancer types. Exploring the molecular mechanisms driving malignant proliferation and …

Ubiquitin (Ub) is a highly conserved protein utilized by all eukaryotes, central to signaling for
nearly every cellular process documented. These processes include protein degradation …