The importance of protein domain mutations in cancer therapy

CK Kumar, A Emerson - Heliyon, 2024 - cell.com
Cancer is a complex disease that is caused by multiple genetic factors. Researchers have
been studying protein domain mutations to understand how they affect the progression and …

Identifying individuals using proteomics: are we there yet?

I Fierro-Monti, JC Wright, JS Choudhary… - Frontiers in Molecular …, 2022 - frontiersin.org
Multi-omics approaches including proteomics analyses are becoming an integral
component of precision medicine. As clinical proteomics studies gain momentum and their …

Optimization of targeted plant proteomics using liquid chromatography with tandem mass spectrometry (LC-MS/MS)

W Li, AA Keller - ACS Agricultural Science & Technology, 2023 - ACS Publications
This study was conducted to optimize a targeted plant proteomics approach from signature
peptide selection and liquid chromatography with tandem mass spectrometry (LC-MS/MS) …

A systematic investigation of complement and coagulation-related protein in autism spectrum disorder using multiple reaction monitoring technology

X Cao, X Tang, C Feng, J Lin, H Zhang, Q Liu… - Neuroscience …, 2023 - Springer
Autism spectrum disorder (ASD) is one of the common neurodevelopmental disorders in
children. Its etiology and pathogenesis are poorly understood. Previous studies have …

Predicting Mutational Effects on Ca2+-Activated Chloride Conduction of TMEM16A Based on a Simulation Study

Y Zhang, K Wu, Y Li, S Wu, A Warshel… - Journal of the American …, 2024 - ACS Publications
The dysfunction and defects of ion channels are associated with many human diseases,
especially for loss-of-function mutations in ion channels such as cystic fibrosis …

Enhancing protein trap** efficiency of graphene oxide-polybutylene succinate nanofiber membrane via molecular imprinting

N Sathirapongsasuti, A Panaksri, B Jusain… - Scientific Reports, 2023 - nature.com
Filtration of biological liquids has been widely employed in biological, medical, and
environmental investigations due to its convenience; many could be performed without …

Identification of alternative splicing-derived cancer neoantigens for mRNA vaccine development

R Cheng, Z Xu, M Luo, P Wang, H Cao… - Briefings in …, 2022 - academic.oup.com
Messenger RNA (mRNA) vaccines have shown great potential for anti-tumor therapy due to
the advantages in safety, efficacy and industrial production. However, it remains a challenge …

Targeted Mass Spectrometry Analyses of Somatic Mutations in Colorectal Cancer Specimens Using Differential Ion Mobility

Z Wu, É Bonneil, M Belford, C Boeser… - Journal of Proteome …, 2023 - ACS Publications
Identification of K-Ras and B-Raf mutations in colorectal cancer (CRC) is essential to predict
patients' response to anti-EGFR therapy and formulate appropriate therapeutic strategies to …

Application of proteogenomics to urine analysis towards the identification of novel biomarkers of prostate cancer: an exploratory study

T Lima, AS Barros, F Trindade, R Ferreira… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer (PCa) is one of the most common cancers. Due to the
limited and invasive approaches for PCa diagnosis, it is crucial to identify more accurate and …

Conjugation of primary amine groups in targeted proteomics

Y Cai - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Primary amines, in the form of unmodified N‐terminus of peptide/protein and unmodified
lysine residue, are perhaps the most important functional groups that can serve as the …