Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique
biophysical properties: a small headgroup; negative charge; and a phosphomonoester …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

The biogenesis of lipid droplets (LDs) and the development of adipocytes are two key
aspects of mammalian fat storage. SEIPIN, an integral membrane protein of the endoplasmic …

Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …

Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …

Abstract FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and
shape of the endoplasmic reticulum. The structure of its reticulon-homology domain (RHD) …

Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their
structure and by the segregation of hydrophobic and polar residues between two faces of …

Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-
prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has …

Cell shape is well described by membrane curvature. Septins are filament-forming, GTP-
binding proteins that assemble on positive, micrometer-scale curvatures. Here, we examine …