Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …

Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to
the progressive fibrosis and calcification of aortic valve leaflets. In western populations …

Iron is essential for many biological processes. Inadequate or excess amount of body iron
can result in various pathological consequences. The pathological roles of iron in …

Background: Aortic valve stenosis (AVS), which is the most common valvular heart disease,
causes a progressive narrowing of the aortic valve as a consequence of thickening and …

Vascular calcification (VC), an actively regulated process, has been recognized as an
independent and strong predictor of cardiovascular disease (CVD) and mortality worldwide …

Despite the elucidation of the pathways behind the development of aortic stenosis (AS),
there remains no effective medical treatment to slow or reverse its progress. Instead, the …

Background and aims The oxidative metabolism of polyunsaturated fatty acids (PUFAs)
leads to bioactive isoprostanoids. The aim was to establish the associations of a complete …

Vascular adhesion protein-1 (VAP-1) is a semicarbazide-sensitive amine oxidase (SSAO),
whose enzymatic activity regulates the adhesion/exudation of leukocytes in/from blood …

Aortic valve stenosis (AVS), a consequence of increased fibrosis and calcification of the
aortic valve leaflets, causes progressive narrowing of the aortic valve. Proteoglycans …

Calcific aortic valve stenosis (CAVS) is a common age-related disease characterized by
active calcification of the leaflets of the aortic valve. How innate immune cells are involved in …