Despite decades of research, we lack objective diagnostic or prognostic biomarkers of
mental health problems. A key reason for this limited progress is a reliance on the traditional …

A body of pre-clinical evidence shows how the gut microbiota influence brain functioning,
including brain connectivity. Linking measures of brain connectivity to the gut microbiota can …

Purpose To examine the association between dietary magnesium (Mg) intake and brain
volumes and white matter lesions (WMLs) in middle to early old age. Methods Participants …

The benefits of consuming fruits and vegetables are widely accepted. While previous studies
suggest a protective role of fruits and vegetables against a variety of diseases such as …

Background As the global population ages, there has been a growing incidence of
neurodegenerative diseases such as Alzheimer's. More recently, studies exploring the …

Cellular senescence, a hallmark of aging, plays an important role in age-related conditions
among older adults. Targeting senescent cells and its phenotype may provide a promising …

Most societies witness an ever increasing prevalence of both obesity and dementia, a
scenario related to often underestimated individual and public health burden. Overnutrition …

Genetic susceptibility and lifestyle affect the risk of dementia but there is little direct evidence
for their associations with preclinical changes in brain structure. We investigated the …

Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic
loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that …

The hypothalamus is part of the hypothalamic-pituitary-adrenal axis which activates stress
responses through release of cortisol. It is a small but heterogeneous structure comprising …