DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …
tumors. However, the radioresistance of cancer cells is still a major limitation for …
Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer
A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
WEE1 inhibitor: clinical development
A Kong, H Mehanna - Current oncology reports, 2021 - Springer
Purpose of Review WEE1 inhibitor has been shown to potential chemotherapy or
radiotherapy sensitivity in preclinical models, particularly in p53-mutated or deficient cancer …
radiotherapy sensitivity in preclinical models, particularly in p53-mutated or deficient cancer …
Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair
KRAS-activating mutations are oncogenic drivers and are correlated with radioresistance of
multiple cancers, including colorectal cancer, but the underlying precise molecular …
multiple cancers, including colorectal cancer, but the underlying precise molecular …
Safety, antitumor activity, and biomarker analysis in a phase I trial of the once-daily Wee1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors
Abstract Purpose: The Wee1 kinase inhibitor adavosertib abrogates cell-cycle arrest,
leading to cell death. Prior testing of twice-daily adavosertib in patients with advanced solid …
leading to cell death. Prior testing of twice-daily adavosertib in patients with advanced solid …
Targeting the DNA damage response for cancer therapy by inhibiting the kinase Wee1
Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …
Targeting oncogenic KRAS in non-small cell lung cancer with EGFR aptamer-conjugated multifunctional RNA nanoparticles
KRAS mutations are one of the most common oncogenic driver mutations in human cancers,
including non-small cell lung cancer (NSCLC), and have established roles in cancer …
including non-small cell lung cancer (NSCLC), and have established roles in cancer …
A cancer cell selective replication stress nano amplifier promotes replication fork catastrophe to overcome radioresistance
Replication stress (RS) induced by DNA damage plays a significant role in conferring the
anticancer effects of radiotherapy and is tightly associated with radioresistance of cancer …
anticancer effects of radiotherapy and is tightly associated with radioresistance of cancer …
[HTML][HTML] MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction
L Zhang, L Zhang, Y Guo, M **ao, L Feng… - … Pharmaceutica Sinica B, 2021 - Elsevier
Mitotic catastrophe (MC) is a form of programmed cell death induced by mitotic process
disorders, which is very important in tumor prevention, development, and drug resistance …
disorders, which is very important in tumor prevention, development, and drug resistance …
An update of predictive biomarkers related to WEE1 inhibition in cancer therapy
Z Wang, W Li, F Li, R **ao - Journal of Cancer Research and Clinical …, 2024 - Springer
Purpose WEE1 is a crucial kinase involved in the regulation of G2/M checkpoint within the
cell cycle. This article aims to comprehensively review the existing knowledge on the …
cell cycle. This article aims to comprehensively review the existing knowledge on the …