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[HTML][HTML] Genetic heterogeneity, tumor microenvironment and immunotherapy in triple-negative breast cancer
E Kudelova, M Smolar, V Holubekova… - International Journal of …, 2022 - mdpi.com
Heterogeneity of triple-negative breast cancer is well known at clinical, histopathological,
and molecular levels. Genomic instability and greater mutation rates, which may result in the …
and molecular levels. Genomic instability and greater mutation rates, which may result in the …
Advancements and hurdles in the development of a vaccine for triple-negative breast cancer: A comprehensive review of multi-omics and immunomics strategies
Abstract Triple-Negative Breast Cancer (TNBC) presents a significant challenge in oncology
due to its aggressive behavior and limited therapeutic options. This review explores the …
due to its aggressive behavior and limited therapeutic options. This review explores the …
[HTML][HTML] Regulation of Host Immune Response against Enterobacter cloacae Proteins via Computational mRNA Vaccine Design through Transcriptional Modification
Enterobacter cloacae is mainly responsible for sepsis, urethritis, and respiratory tract
infections. These bacteria may affect the transcription of the host and particularly their …
infections. These bacteria may affect the transcription of the host and particularly their …
Design of a potential Sema4A-based multi-epitope vaccine to combat triple-negative breast cancer: an immunoinformatic approach
P Paranthaman, S Veerappapillai - Medical Oncology, 2023 - Springer
Immunotherapy is revam** the therapeutic strategies for TNBC owing to its higher
mutational burden and tumour-associated antigens. One of the most intriguing …
mutational burden and tumour-associated antigens. One of the most intriguing …
Designing a novel SOX9 based multi-epitope vaccine to combat metastatic triple-negative breast cancer using immunoinformatics approach
HN Rajendran Krishnamoorthy, R Karuppasamy - Molecular diversity, 2023 - Springer
Immunotherapies are a promising treatment option especially for the management of TNBC
owing to its higher levels of tumour-associated antigens together with higher mutational …
owing to its higher levels of tumour-associated antigens together with higher mutational …
Design and in silico validation of a novel MZF-1-based multi-epitope vaccine to combat metastatic triple negative breast cancer
HNR Krishnamoorthy, R Karuppasamy - Vaccines, 2023 - mdpi.com
Immunotherapy is emerging as a potential therapeutic strategy for triple negative breast
cancer (TNBC) owing to the immunogenic landscape of its tumor microenvironment …
cancer (TNBC) owing to the immunogenic landscape of its tumor microenvironment …
Novel HER2-based multi-epitope vaccine (HER2-MEV) against HER2-positive breast cancer: In silico design and validation
Breast cancer (BC) continues to be the malignancy with the highest diagnosis rate
worldwide. Between 15% and 30% of BC patients show overexpressed human epidermal …
worldwide. Between 15% and 30% of BC patients show overexpressed human epidermal …
Ectopic expression of tumor suppressive miR-181c-5p downregulates oncogenic Notch signaling in MDA-MB-231 cells
Triple negative breast cancer (TNBC) is a very invasive subtype of breast cancer (BCa), this
is accounted for 15–20% of all BCa cases. TNBC patients have very limited therapy option …
is accounted for 15–20% of all BCa cases. TNBC patients have very limited therapy option …
Identification and targeting of metastatic biomarkers for hepatocellular carcinoma therapeutics using small molecules library of curcumin analogues
The understanding of the molecular basis of complex diseases like hepatocellular
carcinoma (HCC) needs large datasets of multiple genes and proteins involved in different …
carcinoma (HCC) needs large datasets of multiple genes and proteins involved in different …
Tackling suppressive cancer microenvironment by NARF-derived immune modulatory vaccine and its validation using simulation strategies
P Paranthaman, S Veerappapillai - Frontiers in Physics, 2024 - frontiersin.org
Introduction: Targeting tumor microenvironment is beneficial and present an ideal setting for
the development of futuristic immunotherapy. Here, we make use of Nuclear prelamin A …
the development of futuristic immunotherapy. Here, we make use of Nuclear prelamin A …