[HTML][HTML] Genetic heterogeneity, tumor microenvironment and immunotherapy in triple-negative breast cancer

E Kudelova, M Smolar, V Holubekova… - International Journal of …, 2022 - mdpi.com
Heterogeneity of triple-negative breast cancer is well known at clinical, histopathological,
and molecular levels. Genomic instability and greater mutation rates, which may result in the …

Advancements and hurdles in the development of a vaccine for triple-negative breast cancer: A comprehensive review of multi-omics and immunomics strategies

T Dhanushkumar, ME Santhosh, PK Selvam… - Life Sciences, 2024 - Elsevier
Abstract Triple-Negative Breast Cancer (TNBC) presents a significant challenge in oncology
due to its aggressive behavior and limited therapeutic options. This review explores the …

[HTML][HTML] Regulation of Host Immune Response against Enterobacter cloacae Proteins via Computational mRNA Vaccine Design through Transcriptional Modification

M Naveed, K Jabeen, R Naz, MS Mughal, AA Rabaan… - Microorganisms, 2022 - mdpi.com
Enterobacter cloacae is mainly responsible for sepsis, urethritis, and respiratory tract
infections. These bacteria may affect the transcription of the host and particularly their …

Design of a potential Sema4A-based multi-epitope vaccine to combat triple-negative breast cancer: an immunoinformatic approach

P Paranthaman, S Veerappapillai - Medical Oncology, 2023 - Springer
Immunotherapy is revam** the therapeutic strategies for TNBC owing to its higher
mutational burden and tumour-associated antigens. One of the most intriguing …

Designing a novel SOX9 based multi-epitope vaccine to combat metastatic triple-negative breast cancer using immunoinformatics approach

HN Rajendran Krishnamoorthy, R Karuppasamy - Molecular diversity, 2023 - Springer
Immunotherapies are a promising treatment option especially for the management of TNBC
owing to its higher levels of tumour-associated antigens together with higher mutational …

Design and in silico validation of a novel MZF-1-based multi-epitope vaccine to combat metastatic triple negative breast cancer

HNR Krishnamoorthy, R Karuppasamy - Vaccines, 2023 - mdpi.com
Immunotherapy is emerging as a potential therapeutic strategy for triple negative breast
cancer (TNBC) owing to the immunogenic landscape of its tumor microenvironment …

Novel HER2-based multi-epitope vaccine (HER2-MEV) against HER2-positive breast cancer: In silico design and validation

MG Seadawy, MM Lotfy, AA Saeed, AM Ageez - Human Immunology, 2024 - Elsevier
Breast cancer (BC) continues to be the malignancy with the highest diagnosis rate
worldwide. Between 15% and 30% of BC patients show overexpressed human epidermal …

Ectopic expression of tumor suppressive miR-181c-5p downregulates oncogenic Notch signaling in MDA-MB-231 cells

M Shuaib, S Kumar - Pathology-Research and Practice, 2024 - Elsevier
Triple negative breast cancer (TNBC) is a very invasive subtype of breast cancer (BCa), this
is accounted for 15–20% of all BCa cases. TNBC patients have very limited therapy option …

Identification and targeting of metastatic biomarkers for hepatocellular carcinoma therapeutics using small molecules library of curcumin analogues

A Gupta, P Choudhary, S Singh - Molecular Diversity, 2025 - Springer
The understanding of the molecular basis of complex diseases like hepatocellular
carcinoma (HCC) needs large datasets of multiple genes and proteins involved in different …

Tackling suppressive cancer microenvironment by NARF-derived immune modulatory vaccine and its validation using simulation strategies

P Paranthaman, S Veerappapillai - Frontiers in Physics, 2024 - frontiersin.org
Introduction: Targeting tumor microenvironment is beneficial and present an ideal setting for
the development of futuristic immunotherapy. Here, we make use of Nuclear prelamin A …