The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …

The AIDS pandemic continues to present us with unique scientific and public health
challenges. Although the development of effective antiretroviral therapy has been a major …

The AID/APOBECs, a group of cytidine deaminases, represent a somewhat unusual protein
family that can insert mutations in DNA and RNA as a result of their ability to deaminate …

Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …

In addition to the conventional innate and acquired immune responses, complex organisms
have evolved an array of dominant, constitutively expressed genes that suppress or prevent …

The antiretroviral activity of the cellular enzyme APOBEC3G [1] has been attributed to the
excessive deamination of cytidine (C) to uridine (U) in minus strand reverse transcripts, a …

All retroviruses, including HIV-1, display species-specific patterns of infection. The impaired
growth of these retroviruses in foreign and sometimes even in their natural hosts often stems …

The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …

Members of the APOBEC family of cellular cytidine deaminases represent a recently
identified group of proteins that provide immunity to infection by retroviruses and protect the …

Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …