Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) has
become a workhorse in global metabolomics studies with growing applications across …

Proteomics plays a vital role in biomedical research in the post-genomic era. With the
technological revolution and emerging computational and statistic models, proteomic …

The perinatal period represents a critical window for cognitive and immune system
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …

Although the subcellular dynamics of RNA and proteins are key determinants of cell
homeostasis, their characterization is still challenging. Here we present an integrative …

Immunosurveillance of cancer requires the presentation of peptide antigens on major
histocompatibility complex class I (MHC-I) molecules,,,–. Current approaches to profiling of …

Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and
require repair by multiple pathways. Whether transcription blockage contributes to the …

African trypanosomes are dixenous eukaryotic parasites that impose a significant human
and veterinary disease burden on sub-Saharan Africa. Diversity between species and life …

Synthetic mRNA technology is a promising avenue for treating and preventing disease. Key
to the technology is the incorporation of modified nucleotides such as N1 …

Testing for significant differences in quantities at the protein level is a common goal of many
LFQ-based mass spectrometry proteomics experiments. Starting from a table of protein …

The chemical arms race between plants and insects is foundational to the generation and
maintenance of biological diversity. We asked how the evolution of a novel defensive …