Simple Summary Sphingolipids are membrane-associated lipids that are involved in signal
transduction pathways regulating cell death, growth, and migration. In cancer cells …

Simple Summary The tumor microenvironment (TME) is a complicated network composed of
various cells, signaling molecules, and extra cellular matrix. TME plays a crucial role in triple …

Ferroptosis, which is characterized by intracellular iron accumulation and lipid peroxidation,
is a newly described form of regulated cell death that may play a key role in tumour …

Nanoparticle (NP)-mediated drug delivery systems are promising for treating various
diseases. However, clinical translation has been delayed by a variety of limitations, such as …

Abstract SPHK1 (sphingosine kinase type 1) is characterized as a rate-limiting enzyme in
sphingolipid metabolism to phosphorylate sphingosine into sphingosine-1-phosphate (S1P) …

Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from
proliferation to cell death. Sphingolipids are modified in multiple cancers and are …

Background The mechanism by which immune cells regulate metastasis is unclear.
Understanding the role of immune cells in metastasis will guide the development of …

Sphingosine 1‐phosphate (S1P) is a bioactive lipid that binds to a family of G protein‐
coupled receptors (S1P1–5) and intracellular targets, such as HDAC1/2, that are functional …

Pancreatic ductal adenocarcinoma (PDAC), has recently been found to be a heterogeneous
disease, although the extension of its diversity remains to be fully understood. Here, we …