Sleep is a universal, essential biological process. It is also an invaluable window on
consciousness. It tells us that consciousness can be lost but also that it can be regained, in …

Expressions such as 'sleep on it'refer to the resolution of distressing experiences across a
night of sound sleep. Sleep is an active state during which the brain reorganizes the …

The noradrenergic locus coeruleus (LC) regulates arousal levels during wakefulness, but its
role in sleep remains unclear. Here, we show in mice that fluctuating LC neuronal activity …

The presymptomatic phase of Alzheimer disease (AD) starts with the deposition of amyloid-β
in the cortex and begins a decade or more before the emergence of cognitive decline. The …

Childhood adversity is a prominent predisposing risk factor for latent stress vulnerability,
expressed as an elevated likelihood of develo** stress-related psychopathology upon …

Continuous sleep restores the brain and body, whereas fragmented sleep harms cognition
and health. Microarousals (MAs), brief (3-to 15-s-long) wake intrusions into sleep, are …

This review presents a comprehensive guide for optimizing medication management in
older adults with depression within an outpatient setting. Medication optimization involves …

We investigated the developmental changes in high-frequency oscillation (HFO) and
Modulation Index (MI)–the coupling measure between HFO and slow-wave phase. We …

Sleep fragmentation (SF) is a common sleep problem experienced during the perioperative
period by older adults, and is associated with postoperative cognitive dysfunction (POCD) …

Alzheimer's disease (AD) is the most prevalent dementia, pathologically featuring abnormal
accumulation of amyloid-β (A β) and hyperphosphorylated tau, while sleep, divided into …