Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …

Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, sha** adaptive and innate immunity. Over the years, a …

The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the
immune response. However, the full diversity of lymph node (LN) SCs remains undefined …

During metazoan development, immune surveillance and cancer dissemination, cells
migrate in complex three-dimensional microenvironments,–. These spaces are crowded by …

Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Patients with cancer have an increased risk of thromboembolism, which is the second
leading cause of death in these patients. Several mechanisms of the prothrombotic state in …