Engineering of global transcription factors in Bacillus, a genetic tool for increasing product yields: a bioprocess overview

SEM Tolibia, AD Pacheco, SYG Balbuena… - World Journal of …, 2023 - Springer
Transcriptional factors are well studied in bacteria for their global interactions and the effects
they produce at the phenotypic level. Particularly, Bacillus subtilis has been widely …

The aminoshikimic acid pathway in bacteria as source of precursors for the synthesis of antibacterial and antiviral compounds

A Escalante, R Mendoza-Flores… - Journal of Industrial …, 2021 - academic.oup.com
The aminoshikimic acid (ASA) pathway comprises a series of reactions resulting in the
synthesis of 3-amino-5-hydroxybenzoic acid (AHBA), present in bacteria such as …

Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria

J Shi, Z Feng, J Xu, F Li, Y Zhang… - Proceedings of the …, 2023 - National Acad Sciences
In actinobacteria, an OmpR/PhoB subfamily protein called GlnR acts as an orphan response
regulator and globally coordinates the expression of genes responsible for nitrogen, carbon …

Transcriptional self-regulation of the master nitrogen regulator GlnR in mycobacteria

J He, X Kang, J Wu, Z Shao, Z Zhang, Y Wu… - Journal of …, 2023 - Am Soc Microbiol
As a master nitrogen regulator in most actinomycetes, GlnR both governs central nitrogen
metabolism and regulates many carbon, phosphate, and secondary metabolic pathways. To …

Research progress on GlnR-mediated regulation in Actinomycetes

B Gao, G Li, D Gu, J Wang - Frontiers in Microbiology, 2023 - frontiersin.org
This review constitutes a summary of current knowledge on GlnR, a global regulator, that
assumes a critical function in the regulation of nitrogen metabolism of Actinomycetes. In …

The global nitrogen regulator GlnR is a direct transcriptional repressor of the key gluconeogenic gene pckA in actinomycetes

X Liu, X Wang, Z Shao, J Dang, W Wang… - Journal of …, 2024 - Am Soc Microbiol
In most actinomycetes, GlnR governs both nitrogen and non-nitrogen metabolisms (eg,
carbon, phosphate, and secondary metabolisms). Although GlnR has been recognized as a …