[HTML][HTML] Combination anticancer therapies using selected phytochemicals

WH Talib, D Awajan, RA Hamed, AO Azzam… - Molecules, 2022 - mdpi.com
Cancer is still one of the most widespread diseases globally, it is considered a vital health
challenge worldwide and one of the main barriers to long life expectancy. Due to the …

[HTML][HTML] Emerging therapeutic strategies to overcome drug resistance in cancer cells

P Garg, J Malhotra, P Kulkarni, D Horne, R Salgia… - Cancers, 2024 - mdpi.com
Simple Summary This review explores the challenges of drug resistance in cancer treatment
and discusses innovative strategies to overcome them. Researchers aim to understand how …

Kaempferol can reverse the 5-Fu resistance of colorectal cancer cells by inhibiting PKM2-mediated glycolysis

H Wu, J Du, C Li, H Li, H Guo, Z Li - International Journal of Molecular …, 2022 - mdpi.com
Resistance to 5-Fluorouracil (5-Fu) chemotherapy is the main cause of treatment failure in
the cure of colon cancer. Therefore, there is an urgent need to explore a safe and effective …

Remodeling tumor microenvironment with natural products to overcome drug resistance

W Zhang, S Li, C Li, T Li, Y Huang - Frontiers in immunology, 2022 - frontiersin.org
With cancer incidence rates continuing to increase and occurrence of resistance in drug
treatment, there is a pressing demand to find safer and more effective anticancer strategy for …

Linarin, a glycosylated flavonoid, with potential therapeutic attributes: A comprehensive review

J Mottaghipisheh, H Taghrir, A Boveiri Dehsheikh… - Pharmaceuticals, 2021 - mdpi.com
Many flavonoids, as eminent phenolic compounds, have been commercialized and
consumed as dietary supplements due to their incredible human health benefits. In the …

[HTML][HTML] Phytochemicals in drug discovery—A confluence of tradition and innovation

P Chihomvu, A Ganesan, S Gibbons… - International journal of …, 2024 - mdpi.com
Phytochemicals have a long and successful history in drug discovery. With recent
advancements in analytical techniques and methodologies, discovering bioactive leads from …

[HTML][HTML] Microalgal carotenoids: therapeutic application and latest approaches to enhance the production

P Sirohi, H Verma, SK Singh, VK Singh… - Current Issues in …, 2022 - mdpi.com
Microalgae are microscopic photosynthetic organisms frequently found in fresh and marine
water ecosystems. Various microalgal species have been considered a reservoir of diverse …

NPs loaded with zoledronic acid as an advanced tool for cancer therapy

S Fathi-karkan, M Zeeshan, M Qindeel… - Journal of Drug Delivery …, 2023 - Elsevier
Zoledronic acid (ZA) has been shown to be beneficial against cancer both directly and
indirectly. However, because of its fast absorption by bone, its use in extraskeletal …

Chalcones and gastrointestinal cancers: experimental evidence

R Michalkova, M Kello, M Cizmarikova… - International Journal of …, 2023 - mdpi.com
Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers
with a high incidence rate worldwide. The current treatment including surgery …

[HTML][HTML] Quinone scaffolds as potential therapeutic anticancer agents: Chemistry, mechanism of Actions, Structure-Activity relationships and future perspectives

S Faizan, MMA Mohsen, C Amarakanth, A Justin… - Results in …, 2024 - Elsevier
Quinone compounds have emerged as promising candidates for the development of
anticancer drugs. Their unique chemical properties and their ability to participate in redox …