Abstract c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however,
emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK …

A severe lack of early diagnosis coupled with resistance to most available therapeutic
options renders pancreatic cancer as a major clinical concern. The limited efficacy of current …

Macrophage activation is controlled by a balance between activating and inhibitory
receptors,,,,,–, which protect normal tissues from excessive damage during infection, but …

The extracellular domain of plasma membrane integrin αvβ3 contains a cell surface receptor
for thyroid hormone analogues. The receptor is largely expressed and activated in tumor …

Advanced or metastatic pancreatic cancer is highly resistant to existing therapies, and new
treatments are urgently needed to improve patient outcomes. Current studies focus on …

Pancreatic cancer (PC) is one of the most aggressive forms of cancer. Negative prognosis is
mainly due to the late diagnosis in advanced stages, when the disease is already …

Gastrointestinal cancers are a leading cause of cancer morbidity and mortality worldwide
with 4.2 million new cases and 3.2 million deaths estimated in 2020. Despite the advances …

Recent mounting evidence has revealed extensive genetic heterogeneity within tumors that
drive phenotypic variation affecting key cancer pathways, making cancer treatment …

Prostate cancer (PC), which has high morbidity and mortality among elderly men, is
becoming the most common malignancy in men. The progression of PC is associated with …

Cisplatin resistance is a major therapeutic challenge in advanced head and neck squamous
cell carcinoma (HNSCC). Here, we aimed to investigate the key signaling pathway for …