Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …

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Background Pneumococcal conjugate vaccines have reduced the incidence of invasive
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …

Progress has been made in the prevention and treatment of community-acquired bacterial
meningitis during the past three decades but the burden of the disease remains high …

Microbiology is at a turning point in its 120-year history. Widespread next-generation
sequencing has revealed genetic complexity among bacteria that could hardly have been …

Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …

Discovery of genetic variants underlying bacterial phenotypes and the prediction of
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …

Abstract Group B Streptococcus (GBS), or Streptococcus agalactiae, is a pathogen that
causes preterm births, stillbirths, and acute invasive neonatal disease burden and mortality …

The advent of inexpensive and rapid sequencing technologies has allowed bacterial whole-
genome sequences to be generated at an unprecedented pace. This wealth of information …