Rho-class small GTPases are implicated in basic cellular processes at nearly all brain
developmental steps, from neurogenesis and migration to axon guidance and synaptic …

The Wnt pathway is an integral cell-to-cell signaling hub which regulates crucial
development processes and maintenance of tissue homeostasis by coordinating cell …

Electrospinning is a well-known, straightforward, and versatile technique, widely used for the
preparation of fibers by electrifying a polymer solution. However, a high molecular weight is …

Poor colloidal stability of gold nanoparticles (AuNPs) in physiological environments remains
one of the major limitations that contribute to their difficult translation from bench to clinic. For …

We prepared a small library of short peptidomimetics based on 3-pyrrolo-pyrazole
carboxylate, a non-coded γ-amino acid, and glycine or alanine. The robust and eco-friendly …

A fundamental role of pancreatic β-cells to maintain proper blood glucose level is controlled
by the Ras superfamily of small GTPases that undergo post-translational modifications …

Intellectual disability (ID) is a pathological condition characterized by limited intellectual
functioning and adaptive behaviors. It affects 1–3% of the worldwide population, and no …

The Tiam family proteins—Tiam1 and Tiam2/STEF—are Rac1-specific Guanine Nucleotide
Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other …

The main goal in develo** peptidomimetics is the stabilization of the bioactive
conformation of peptides. Among all the secondary structures, turns are of paramount …

A new non-natural β-amino acid, named 3-Ar-β-Morph, was designed and synthesized via a
regio-and diastereoselective Pd-catalyzed C (sp3) H-arylation of the corresponding 2 S, 6 S …