The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

A cell's decision to die is controlled by a sophisticated network whose deregulation
contributes to the pathogenesis of multiple diseases including neoplastic and …

Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar
over respiration. We now reveal an evolutionary conserved mechanism linking fermentation …

Many disease states, including the aging process, are associated with the accumulation of
mitochondria harboring respiratory dysfunction. Mitochondrial dysfunction is often …

Dysfunctional mitochondria show a reduced capacity for fusion and, as mitochondrial fission
is maintained, become spatially separated from the intact network. By that mechanism …

Regulation of cell growth by nutrients is governed by highly conserved signaling pathways,
yet mechanisms of nutrient sensing are still poorly understood. In yeast, glucose activates …

Domestication of plants and animals is the foundation for feeding the world human
population but can profoundly alter the biology of the domesticated species. Here we …

Mitochondria autophagy (mitophagy) is a process that selectively degrades mitochondria via
autophagy. Recently, there has been significant progress in the understanding of mitophagy …

The complexity of many cellular and organismal traits results from the integration of genetic
and environmental factors via molecular networks. Network structure and effect propagation …

Yeast (Saccharomyces cerevisiae) can undergo cell death accompanied by diagnostic
features of apoptosis, such as phosphatidylserine externalization, DNA fragmentation …