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Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
Host-directed antiviral therapy
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
KT Choy, AYL Wong, P Kaewpreedee, SF Sia, D Chen… - Antiviral research, 2020 - Elsevier
Highlights•Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC 50 at 23.15
μM.•Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC 50 at 26.63 μM.• …
μM.•Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC 50 at 26.63 μM.• …
High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses
Coronaviruses (CoVs) act as cross-species viruses and have the potential to spread rapidly
into new host species and cause epidemic diseases. Despite the severe public health threat …
into new host species and cause epidemic diseases. Despite the severe public health threat …
Alkaloids as potential antivirals. A comprehensive review
Alkaloids are a diverse group of natural phytochemicals. These phytochemicals in plants
provide them protection against pests, and herbivorous organisms and also control their …
provide them protection against pests, and herbivorous organisms and also control their …
Biologically active isoquinoline alkaloids covering 2014–2018
XF Shang, CJ Yang… - Medicinal research …, 2020 - Wiley Online Library
Isoquinoline alkaloids, an important class of N‐based heterocyclic compounds, have
attracted considerable attention from researchers worldwide since the early 19th century …
attracted considerable attention from researchers worldwide since the early 19th century …
Isolation and characterization of lumpy skin disease virus from cattle in India
Lumpy skin disease (LSD) has devastating economic impact. During the last decade, LSD
had spread to climatically new and previously disease-free countries, which also includes its …
had spread to climatically new and previously disease-free countries, which also includes its …
[HTML][HTML] Potential antiviral action of alkaloids
Viral infections and outbreaks have become a major concern and are one of the main
causes of morbidity and mortality worldwide. The development of successful antiviral …
causes of morbidity and mortality worldwide. The development of successful antiviral …
[HTML][HTML] Potential antiviral options against SARS-CoV-2 infection
As of June 2020, the number of people infected with severe acute respiratory coronavirus 2
(SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the …
(SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the …
Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry
The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued
threats to the global public health. Effective therapeutics for these maladies is an unmet …
threats to the global public health. Effective therapeutics for these maladies is an unmet …