Liver regeneration and inflammation: from fundamental science to clinical applications
Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
Machine perfusion in liver transplantation
RX Sousa Da Silva, A Weber, P Dutkowski… - …, 2022 - Wiley Online Library
Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …
Transplantation of a human liver following 3 days of ex situ normothermic preservation
Current organ preservation methods provide a narrow window (usually< 12 hours) to
assess, transport and implant donor grafts for human transplantation. Here we report the …
assess, transport and implant donor grafts for human transplantation. Here we report the …
[HTML][HTML] Utilization of livers donated after circulatory death for transplantation–An international comparison
J Eden, RXS Da Silva, M Cortes-Cerisuelo… - Journal of …, 2023 - Elsevier
Background & Aims Liver graft utilization rates are a hot topic due to the worldwide organ
shortage and the increasing number of transplant candidates on waiting lists. Liver perfusion …
shortage and the increasing number of transplant candidates on waiting lists. Liver perfusion …
Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: A European observational cohort study
A short period (1–2 h) of hypothermic oxygenated machine perfusion (HOPE) after static
cold storage is safe and reduces ischemia‐reperfusion injury‐related complications after …
cold storage is safe and reduces ischemia‐reperfusion injury‐related complications after …
Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation
A lack of accepted standards and standardized phantoms suitable for the technical
validation of biophotonic instrumentation hinders the reliability and reproducibility of its …
validation of biophotonic instrumentation hinders the reliability and reproducibility of its …
Machine perfusion of the liver: applications in transplantation and beyond
The shortage of donor livers considered suitable for transplantation has driven the
development of novel methods for organ preservation and reconditioning. Machine …
development of novel methods for organ preservation and reconditioning. Machine …
Partial freezing of rat livers extends preservation time by 5-fold
The limited preservation duration of organs has contributed to the shortage of organs for
transplantation. Recently, a tripling of the storage duration was achieved with supercooling …
transplantation. Recently, a tripling of the storage duration was achieved with supercooling …
[HTML][HTML] Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: What does the future have in store for us?
B Lascaris, VE de Meijer, RJ Porte - Journal of Hepatology, 2022 - Elsevier
Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …
are registered on waiting lists than there are available donor livers for transplantation. High …
[HTML][HTML] Hydrogels derived from decellularized liver tissue support the growth and differentiation of cholangiocyte organoids
Human cholangiocyte organoids are promising for regenerative medicine applications, such
as repair of damaged bile ducts. However, organoids are typically cultured in mouse tumor …
as repair of damaged bile ducts. However, organoids are typically cultured in mouse tumor …